| 2005 Press Releases &
Internal Center News Bulletin
Headlines
Articles 12 December: Darlene
Taylor Moves to NCCU 06 December: Dr.
Anastas Named Scientific American Please visit the links below for more
information: 05 December: Safety
Reminder 08 November: Activities of Green
Chemistry Institute 24 October: Conductive Plastics
21 October: Dr. Eleanor Enthoven Hasse Joins EAB 10 October 2005: National Cancer Institute Award Researchers at UNC have received an award from the National Cancer Institute (NCI) expected to total approximately $20 million over five years. The UNC research team includes a very diverse mix of scientists and physicians from at least seven disciplines and includes researchers from Duke, NC State and UC San Francisco. A key contributor to this effort is Prof. Joe DeSimone, William R. Kenan Jr. distinguished professor of chemistry and chemical engineering at UNC and N.C. State and also a UNC Lineberger member. Research done by Joe and his group in the NSF Science and Technology Center for Environmentally Responsible Solvents and Processes (CERSP) led to the development of a feasible method to produce solvent-resistant organic polymer nanostructures. The breakthrough discovery in this process is a crosslinkable liquid fluoroelastomer of a type first made in CO2. Patents underlying the proposed NCI work were based on work partially supported by CERSP and include both nanoparticles and microfluidic devices. This technology, called Particle Replication in Non-Wetting Templates (PRINT), makes it possible to produce nanoparticles uniform in size and shape. These nanoparticles can be "loaded" with X-ray or MRI contrast agents or medicines. The nanoparticles are "smart" in that they will be formulated to interact with receptors on specific cell types and release their "cargo" on contact. One possible result is better, more targeted delivery of drugs in the body. "We are thrilled to be part of NCI’s team of nanotechnology centers," DeSimone said. "This support will enable our vision to dramatically improve the diagnosis and treatment of cancer by tapping into technologies from the electronics industry traditionally used for the fabrication of highly uniform nanoscale transistors and applying them to the fabrication of highly precise, shape-specific nanoscale vehicles for the direct delivery of therapeutics and imaging agents to individual cancer cells." To read the full press release click here
UNC Lineberger receives one of seven large NCI grants for small science CHAPEL HILL -- The National Cancer Institute has named the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center as one of seven institutions nationwide in the NCI Alliance for Nanotechnology in Cancer. The funds for the first year of this five-year award total $3,899,965 and will establish the Carolina Center of Cancer Nanotechnology Excellence. Officials said the grant would fund projects to harness emerging developments in nanotechnology to improve cancer diagnostics and imaging and therapy, and create new jobs for North Carolina. Dr. Rudy Juliano, professor of pharmacology in UNC’s School of Medicine and UNC Lineberger member, has been contributing to this field for more than two decades and is principal investigator of the grant. "The UNC group of investigators is diverse and comes from across campus and disciplines. Chemists, physicists, engineers, tumor biologists, pharmacologists, oncologists and radiologists are all working together to translate opportunities created by new developments in nanotechnology into better care for cancer patients. Our faculty was joined by collaborators from North Carolina State University, Duke and the University of California at San Francisco." Cancer nanomedicine results from a convergence of the biological and physical sciences. Scientists have learned that cells function as assemblies of biological nanomachines, and abnormalities of cancer and other diseases often are based on malfunction of those nanomachines. In the physical sciences, the properties of matter on the nanoscale differ greatly from matter on a normal scale. "Nano" usually is defined as less than 100 nanometers in size (about 0.000004 inches). Despite this tiny size, complex nanoscale devices now can be created and manipulated. Such nanodevices produced by physicists, chemists and engineers can be used to sense or to manipulate events around, on or even within, cells. This offers the possibility of bringing the power of physical science to bear on problems of biomedical research, with implications for therapy, diagnosis, and early detection of cancer and other diseases. "Our inclusion in this NCI program with some of the world’s premier physical science universities is a tribute to UNC’s ability to put together teams across academic boundaries," said Dr. Shelton Earp, UNC Lineberger director. "This synthesis of engineering, material science and medicine is both the future of patient care and attractive to industry at all levels." "With recent ratings placing the Research Triangle as a top region for startup companies, large grants such as this one attract scientists and fuel economic development. New companies will be spawned as technologies mature and need to be developed and marketed to the health-care industry. This result is one small way of validating the state’s tremendous investment in the university and UNC Health Care System." Several promising technologies will shape the research, including new developments in nanoparticle fabrication, X-ray nanotechnology and nanofluidics. Dr. Joe DeSimone, William R. Kenan Jr. distinguished professor of chemistry and chemical engineering at UNC and N.C. State and also a UNC Lineberger member, is developing "smart" nanoparticles. Through a technology he developed at UNC called Particle Replication in Non-Wetting Templates (PRINT), he is able to make nanoparticles uniform in size and shape. These nanoparticles can be "loaded" with X-ray or MRI contrast agents or medicines. The nanoparticles are "smart" in that they will be formulated to interact with receptors on specific cell types and release their "cargo" on contact. One result is better, more targeted delivery of drugs in the body. "We are thrilled to be part of NCI’s team of nanotechnology centers," DeSimone said. "This support will enable our vision to dramatically improve the diagnosis and treatment of cancer by tapping into technologies from the electronics industry traditionally used for the fabrication of highly uniform nanoscale transistors and applying them to the fabrication of highly precise, shape-specific nanoscale vehicles for the direct delivery of therapeutics and imaging agents to individual cancer cells." Dr. Otto Zhou, professor of physics and astronomy in UNC’s College of Arts and Sciences and a UNC Lineberger member, is developing a new method of medical X-ray imaging based on pulsed nanofibers. The pulsed emission nanofiber system captures images of the body or a specific organ while they are moving. The result, Zhou said, is more precise and sensitive X-rays providing earlier detection of tumors before they get too large to treat, as well as an easier procedure for the patient. Dr. John Ramsey, professor of chemistry in UNC’s College of Arts and Sciences, is working on "nanofluidics" devices perhaps more easily understood as "labs on a chip." Using this technology, a "nanofluidics" machine the size of a playing card will analyze one drop of blood and have almost instantaneous results on a vast array of blood measurements. Other institutions named as Centers of Cancer Nanotechnology Excellence are: the California Institute of Technology, the University of California at San Diego, Emory University and the Georgia Institute of Technology, the Massachusetts Institute of Technology and Harvard University, Northwestern University and Washington University in St. Louis.
For more information about UNC’s ongoing research in nanotechnology, visit
http://research.unc.edu/endeavors/fall2005/zhou.php and
For more information regarding this NCI award, visit http://nano.cancer.gov/alliance_awards/press/pr_2005_10_03.asp For more information on nanotechnology in cancer treatment, visit http://nano.cancer.gov/ 29 September: NSF 2005 Site Review 28 September: On-Line Ethics Training
19 September: Innovation Day Symposium 14
September: Computer Resource for NC High Schools 09
September: Draft Plan On-line 08 September: Post-doc position at NCA&T
State University 22 June: DeSimone Recognized by
CEDNC 17 June: DOE Funds CERSP Spin-off Principle investigator is
Prof. Joseph M. DeSimone, William R. Kenan Jr.
27 May:
Samulski Named
Jefferson Science Fellow
26 May: Immersion Lithography Webcast Available Originally broadcast April 5th, speakers detailed the use of 193 nm immersion lithography in a production environment, as well as issues still to be tackled during a session at the 2005 Electronics Manufacturing Summit. The webcast is complimentary. Register Now. 19 May: New Safety Information Available 16 May: DeSimone Elected to Academy of Arts and Sciences Prof. Joseph M. DeSimone has been elected Fellow of the American Academy of Arts and Sciences in recognition of "preeminent contributions" in his field. This brings the total number of UNC faculty members who have been elected to academy membership to 27. Among the 196 fellows and 17 foreign honorary members named to the academy this year are U.S. Supreme Court Chief Justice William Rehnquist, painter Jeff Koons, Nobel Prize-winning physicist Eric Cornell, journalist Tom Brokaw and Nobel Prize-winning Polish poet Wislawa Szymborska. DeSimone is Kenan distinguished professor of chemistry and chemical engineering in UNC's College of Arts and Sciences and at N.C. State University. He has been a member of the college's faculty since receiving his doctorate from Virginia Polytechnic Institute and State University in 1990. He received his bachelor's degree from Ursinus College in 1986. DeSimone, who holds more than 100 U.S. patents, has been widely recognized as an innovative polymer scientist and for discovering revolutionary ways to use carbon dioxide in place of conventional organic solvents for environmentally responsible manufacturing, cleaning and processing. Earlier this year, DeSimone was elected to membership in the National Academy of Engineering, one of the highest honors in the field. He is the youngest member of NAE. In addition, he directs the National Science Foundation's Science Technology Center for Environmentally Responsible Solvents and Processes, a collaborative endeavor with five universities. DeSimone also directs UNC's new Institute for Advanced Materials, Nanoscience and Technology, an interdisciplinary endeavor drawing on UNC research strengths in polymer science, nanomaterials and nanobiosciences, and involving faculty from the curriculum in applied and materials sciences, and the departments of chemistry, computer science, mathematics, and physics and astronomy. The American Academy of Arts and Sciences was founded in 1780 by our nation’s leaders to cultivate the arts and sciences. It is one of the oldest learned societies in the country and is unique in its breadth and scope. Throughout its history it has gathered individuals with diverse interests and perspectives to participate in studies and projects focusing on critical social and scholarly issues. Prof. DeSimone will be inducted in ceremonies to be held on October 8, 2005 in Cambridge, Massachusetts. Excerpted in part from May 2, 2005 General Alumni Association Newsletter 26 April:
DeSimone in
Fuel Cell Initiative "We think Carolina can have a big impact by making breakthroughs in basic science that can fundamentally transform the way power is harnessed from fuel cells," said DeSimone, W. R. Kenan, Jr. distinguished professor of chemistry and chemical engineering at UNC and N. C. State University. DeSimone also directs the National Science Foundation (NSF) Science and Technology Center for Environmentally Responsible Solvents and Processes and the new Institute for Advanced Materials, Nanoscience and Technology at UNC. First devised in 1839, fuel cells are not currently used widely in commercial industry. Researchers believe they have the potential to provide energy for a wide range of applications, such as powering laptops, providing light and heat to homes and running automobiles. Fuel cell markets are currently valued at nearly $1 billion and are expected to grow to more than $13 billion in the next decade, according to projections cited by the N. C. Fuel Cell Alliance. "You can use fuel cells anywhere you use batteries. For example, if you used a fuel cell in a laptop it could last about a week, instead of lasting a few hours with batteries," said Everett Baucom, Deputy Director of the NSF Science and Technology Center and adjunct professor of chemistry at UNC. "Then, instead of recharging the cell you would simply replace the fuel cartridge." UNC's fuel cell research will focus on portable uses for the technology, including laptops, cellular phones and U.S. Departments of Defense and Homeland Security applications, DeSimone said. Fuel cells offer high automotive fuel efficiency, low emissions and silent operation. UNC researchers are taking this field in a new direction, said DeSimone. "Most of the PEMs used in fuel cell manufacture are solid materials. We are pioneering liquid precursors. Having a liquid precursor can open new ways of fabricating fuel cells." By Mary Catherine Hendrix, a senior with a double major in
psychology and journalism and mass communications. 08 April: Varun Dhanuka Receives
Award 23 March: Dr. Mary Louise Bellamy
to Receive NCSU Award 11 March: "Fueled by UNC/NCSU
technology, startup raises $2.2M" article by Leo John from
Triangle Business Online Liquidia Technologies was founded to commercialize a new type of material developed by Joe DeSimone, a chemistry and chemical engineering professor at both UNC and NCSU, and Edward T. Samulski, a chemistry professor at UNC. They hope to raise another $300,000 to close the round at $2.5 million. Investors funding the round include individual angles, CTI Molecular Imaging, a Knoxville, Tenn.-based medical device company, and Firelake Capital Management, a Palo Alto, Calif.-based investment firm. The capital should allow the company to sustain development for a year, says Bruce Boucher, Liquidia’s president. Boucher says a local venture fund – he declined to say which one – is considering topping off the round with $300,000. “We ended up turning other investors down,” says Boucher, a former finance chief of Magellan Laboratories, which was sold to Cardinal Health in 2002. Magellan co-founder Lowry Caudill has signed on as a member of Liquida’s board of directors. In an e-mail response, DeSimone wrote that he is not prepared to discuss the company’s financing. Liquidia plans to deploy the money to set up operations. The seven hires would bring the employee roster to 12 for the company, which plans to move into 4,400 square feet of office space at Keystone Park in May. Besides being an investor in the company, CTI Molecular Imaging could be a boost in another way. CTI, which sells medical equipment such as positron emission tomography, or PET, machines, in December licensed Liquidia’s material to develop its own devices. Liquidia will earn royalties from any product sales. Liquidia’s material – a liquid at room temperature – becomes a powerful solid when exposed to light for a few minutes. The resulting material combines properties of silicon and glass and makes new application possible, the company says. Possible uses for Liquidia’s technology are in microfluidics, a technology applied to create the flow of liquids in miniature applications – such as ink in a printer cartridge. It also might be used to create molds during the manufacture of microchips and to produce large quantities of nanotech particles. Boucher says Liquidia’s material can be used to improve existing products as well as to create new ones. For DeSimone, Liquidia Technologies is his third technology venture. In 1995, he launched Micell Technologies, a company that developed a novel technology to dry clean clothes. He also founded BioStent, which in 2003 was bought by Guidant Corp. in a two-phase deal worth $16 million. 21 February: UNC
Tops for Science Post Docs 16 February:
DeSimone
Elected to National Academy of Engineering 14 February:
Hall and
DeSimone Selected for NAE 13 February:
Desmond
Harvey's Work Recognized 10 Feburary:
Green
Chemistry Summer School 06 February:
Kropp
Receives Teaching Award 03 February 2005:
Qian
Zhao Recognized 30 January 2005:
Saunders Recognized by
Nanotech Foundation Saunders’ research has focused on two areas: developing very high quality solutions-phase nanocrystal syntheses and understanding spontaneous nanocrystal self-assembly into superlattices. His work bears directly on developing a new class of materials and the processes involved in nanocrystal assembly. His Ph.D. advisor, UT professor Brian Korgel, said his research is “based on his own independent innovations and observations in the laboratory and are remarkable for a graduate student at this point in his studies.” In a key paper Saunders et al describe the single-step self-organization of nanocrystal superlattice films infused with spatially ordered arrays of micrometer-size pores. In a humid atmosphere, water droplets condense on the surface of evaporating thin-film solutions of nanocrystals. Nanocrystals coated with the appropriate ligands stabilize the water droplets, allowing them to grow to uniform size and ultimately pack into very ordered arrays. The droplets provide a temporary template that casts an ordered macroporous nanocrystal film. This process could serve as a reliable bottom-up self-assembly approach for fabricating two-dimensional waveguides with tunable optical properties for single-chip integration of photonic and electronic technologies. Details of the NFT and Kozmetsky Award The NFT established the George Kozmetsky Award for Outstanding Graduate Research in Nanotechnology as a result of generous donations from the public. It is given annually to the top two graduate students in the state of Texas to recognize excellence in nanotechnology research. The awarded funds will be used for stipend, travel, lab supplies, books, equipment and other direct costs associated with the student’s research. The winners will also have an opportunity to address the 2005 Nano Summit that takes place on July 28, 2005. The
Graduate Research Awards are the first awards of their kind to be offered in
the U.S. to students working in fields related to nanotechnology. According
to Conrad Masterson, founder and president of NFT, “These awards
recognize the great work underway at Texas universities. Our goal is to help
attract the brightest young people in the nation to conduct nanotechnology
research; make groundbreaking discoveries; and commercialize products that
derive from their work in this state." 28 January 2005:
UT
Startup in Business Week 12 January 2005 :
Uitenham to Active
Duty 06 January 2005:
Summer Research
Experience 04 January 2005:
DeSimone Featured
Entrepreneur |